Use:
SSRI. Coincidental alleviation of depressing illness: Initially, usually the morning, a single daily dose 25 mg. Ill incurious in one dose 25 mg they can be profited from the increases of doses, in 12.5 increases mg/ime'ra, in intervals of at least 1 week, in one biggest 62.5 mg/ime'ra. Coincidental alleviation of agitation of panic: Initially, usually the morning, a single daily dose 12.5 mg. The changes of doses in intervals of at least 1 week should present itself in 12.5 increases mg/ime'ra. Biggest dose: 75 mg/ime'ra. Social phobia (social agitation of concern): Initially, usually the morning, a single daily dose 12.5 mg. Ill incurious in one dose 12.5 mg they can be profited from the increases of doses, in 12.5 increases mg/ime'ra, in intervals of at least 1 week, in one biggest 37.5 mg/ime'ra.Contraindications:
Not to be used with an MAOI or within 14 days of starting or discontinuing MAOI therapy. Concomitant administration of thioridazine. Contraindicated in patients < 18 years of age due to possible increased risk of suicide-related events in this patient populations.
Precautions:
Not recommended for use during pregnancy, in nursing mothers. Epileptic patients, glaucoma, neuroleptic malignant syndrome, renal or hepatic impairment, activation of mania/hypomania, suicidal tendency, MI or unstable heart disease. Efficacy/safety of combined Paxil and electroconvulsive therapy has not been studied. Hyponatremia (reversible), abnormal bleeding. If a decision is made to stop Paxil therapy, the drug should be gradually withdrawn, as abrupt discontinuation may cause withdrawal symptoms.
Side effects:
Nausea, somnolence, sweating, tremor, insomnia, asthenia, dry mouth, dizziness, male sexual dysfunction, constipation, diarrhea, decreased appetite.
Interactions:
See Contraindications. MAOIs, Phenobarbital, theophylline, 5HT1 agonists (e.g., sumatriptan), phenytoin, lithium, anticoagulants (increased bleeding), procyclidine, cimetidine, St. John's Wort, drugs highly bound to plasma protein, drugs affecting liver enzymes. Avoid concurrent use of paroxetine and tryptophan.
Supplied:
12.5 mg and 25 mg controlled-release tablets.